Ten winning submissions from a pool of nearly 500 entries have been selected by the National Eye Institute (NEI), part of the National Institutes of Health, for its Audacious Goals challenge, a nationwide competition for compelling, one-page ideas to advance vision science. Each winner will receive a $3,000 prize plus travel expenses to attend the NEI Audacious Goals Development Meeting, Feb. 24-26, 2013, at the Bolger Conference Center in Potomac, Md., outside Washington, D.C.
“The Audacious Goals initiative was born out of the NEI strategic planning process, however it is much more than a standard strategic planning exercise,” said Paul A. Sieving, M.D., Ph.D., NEI director. “We are envisioning the future. When we look back 10 to 12 years from now, what do we want to have accomplished? The Audacious Goals initiative will help propel us into that future.”
The NEI Challenge to Identify Audacious Goals in Vision Research and Blindness Rehabilitationis part of a government-wide effort to bring the best ideas and top talent to bear on our nation’s most pressing challenges through the awarding of prize money, among other types of awards. The challenge sought ideas that support the NEI mission to conduct and support research and other programs aimed at reducing the burden of vision disorders and disease worldwide. Prize competition entries were solicited not only from experts in vision research but from anyone in the private, government, and nonprofit sectors, including scientists, engineers, health care providers, inventors, and entrepreneurs, as well as the general public. Entries were de-identified and reviewed by experts on the basis of relevance to the NEI mission and whether the idea is bold, daring, unconventional, or exceptionally innovative; broad in scope; and potentially attainable in about 10 years.
Within a three-month period, 476 entries were submitted from people across the United States, including Puerto Rico. Topics ranged from regenerative medicine and stem cells to neuroscience, genetics, drug development, and artificial vision and prosthetics.
“We didn’t know what to expect when we issued this challenge,” said Richard S. Fisher, Ph.D., director of NEI’s Office of Program Planning and Analysis, which is spearheading the initiative. “Surprisingly, nearly half of the submissions we received came from people who had never been funded by NIH, which demonstrated that we captured the attention of a wide audience throughout the U.S. We invited anyone with an interest in vision research to submit an idea that began with the phrase, ‘It would be fantastic if…’ and in fact, we received many truly audacious ideas.”
During the judging process, more than 80 experts in the vision community helped narrow the field to 81 final candidates. A federal panel consisting of 13 clinicians and scientists then selected the winning ideas.
The winners and their audacious ideas are:
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Dennis Clegg, Ph.D. |
Regenerative Therapy for Retinal Disease |
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Robert Duvoisin, Ph.D. |
Restoration of Vision by Opto-electronic Stimulation |
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Yingbin Fu, Ph.D. |
Precise Gene Editing In Vivo |
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Steven Pittler, Ph.D. |
Using Molecular Scissors Genome Editing to Cure Ocular Genetic Disease |
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Rajesh Rao, M.D. |
An Audacious Goal: Reprogramming the Retina |
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Tonia Rex, Ph.D. |
Functional and Structural Neuroregeneration |
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Julia Richards, Ph.D. |
Fountains of Youth for the Eye |
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Jeffrey Stern, M.D., Ph.D. |
Endogenous Retinal Repair: Releasing our Inner Salamander |
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Russell Van Gelder, M.D., Ph.D. |
Reversing Retinal Blindness Using Small Molecules |
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Janey Wiggs, M.D., Ph.D. |
Vision BioBank — A Network of Ocular Phenotyping Centers Using Genomic and Epidemiologic Data to Promote Personalized Ophthalmology |
Next Steps
The winners have been invited to present their ideas at the NEI Audacious Goals Development Meeting, which will include about 200 vision researchers, patient advocates, ophthalmologists, and optometrists from the U.S. and abroad. The selected ideas will be discussed intensively for further expansion, development, and refinement. Following the meeting, NEI staff and members of the National Advisory Eye Council will finalize and publish a set of the most compelling audacious goals for the institute and the broader vision research community to pursue over the next decade.
“The selection of the winning entries marks the true starting point for NEI’s Audacious Goals initiative,” said Dr. Fisher. “We are now at the point where some of the world’s most prominent vision experts can discuss these ideas in-depth, establish a set of audacious goals, and weigh in on how we can realize those goals.”
For more information, visit the Audacious Goals website at http://www.nei.nih.gov/challenge.
