Genetic analysis of samples collected as the Zika virus (ZIKV) spread throughout the Americas after its introduction in 2013 or 2014 has shown that the virus circulated undetected for up to a year in some regions before it came to the attention of public health authorities.
PharmaMar has announced today a licensing agreement with Eczacıbaşı Group to commercialize the marine-derived anticancer drug Aplidin* (plitidepsin) in Turkey. Under the terms of the agreement, PharmaMar will receive an upfront payment as well as development milestones related to the health approval procedure of Aplidin* in this country. PharmaMar will retain exclusive production rights and will supply the finished product to Eczacıbaşı for commercial use.
PharmaMar announces an agreement with Singapore-based Specialised Therapeutics Asia Pte, Ltd to market the marine-based anti-tumour compound of the Company, lurbinectedin (PM1183) for the treatment of platinum-resistant ovarian cancer, small-cell lung cancer, BRCA 1/2 -associated metastatic breast cancer and other future oncology indications in Australia, New Zealand and in 12 Asian countries (Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Papua New Guinea, Philippines, Singapore, Timor-Leste, Thailand and Vietnam).
La Food and Drug Administration (FDA) statunitense ha approvato tocilizumab in formulazione sottocutanea per il trattamento dell’ACG, una grave malattia autoimmune cronica. Tocilizumab è la prima terapia approvata dall’FDA per il trattamento dei pazienti adulti con ACG. Si tratta della sesta indicazione di tocilizumab approvata dall’FDA dal lancio del medicinale nel 2010.
Eggs are produced in the ovary within follicles. After an egg matures, the follicle releases it from the ovary and it passes to the fallopian tube, where it can be fertilized by sperm. Follicles also make hormones, which travel through the bloodstream to other parts of the body.
Microscopy image of a normal mouse embryo (left) and one that is missing ZFP568 (right). Yang P., Macfarlan T., NICHD/NIH
A protein called ZFP568 regulates an important fetal growth hormone called insulin-like growth factor 2 (Igf2), according to a mouse study led by researchers at the National Institutes of Health. The study is one of the first to show that KRAB-zinc finger proteins, which are well-known for silencing viral genes left over from ancient infections, can also play an essential role in fetal and placental development.
Living in racially segregated neighborhoods is associated with a rise in the blood pressure of black adults, while moving away from segregated areas is associated with a decrease — and significant enough to lead to reductions in heart attacks and strokes, a National Institutes of Health-funded study has found.
Nearly 32 million adults in the United States (13 percent of the U.S. population aged 18 and older) consumed more than twice the number of drinks considered binge drinking on at least one occasion, according to a 2013 survey that asked about past-year drinking.
Cervical cancer is a disease in which malignant (cancer) cells form in the tissues of the cervix. Most cases are caused by long-lasting infections with certain types of human papillomavirus (HPV). These infections lead to genetic changes that raise the risk for cervical cancer.